Blocking the Late Sodium Current Reduces Intracellular Sodium Accumulation During Sodium Pump Inhibition
نویسندگان
چکیده
منابع مشابه
Reducing the late sodium current improves cardiac function during sodium pump inhibition by ouabain.
Inhibition by cardiac glycosides of Na(+), K(+)-ATPase reduces sodium efflux from myocytes and may lead to Na(+) and Ca(2+) overload and detrimental effects on mechanical function, energy metabolism, and electrical activity. We hypothesized that inhibition of sodium persistent inward current (late I(Na)) would reduce ouabain's effect to cause cellular Na(+) loading and its detrimental metabolic...
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RATIONALE Although the sodium channel locus SCN10A has been implicated by genome-wide association studies as a modulator of cardiac electrophysiology, the role of its gene product Nav1.8 as a modulator of cardiac ion currents is unknown. OBJECTIVE We determined the electrophysiological and pharmacological properties of Nav1.8 in heterologous cell systems and assessed the antiarrhythmic effect...
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Reactive oxygen species (ROS), including H2O2, cause intracellular calcium overload and ischemia-reperfusion damage. The objective of this study was to examine the hypothesis that H2O2-induced arrhythmic activity and contractile dysfunction are the results of an effect of H2O2 to increase the magnitude of the late sodium current (late INa). Guinea pig and rabbit isolated ventricular myocytes we...
متن کاملIntegrative Physiology Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic
Rationale: Although the sodium channel locus SCN10A has been implicated by genome-wide association studies as a modulator of cardiac electrophysiology, the role of its gene product Nav1.8 as a modulator of cardiac ion currents is unknown. Objective: We determined the electrophysiological and pharmacological properties of Nav1.8 in heterologous cell systems and assessed the antiarrhythmic effect...
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1. Abstract 2. Introduction 3. Sodium Regulation in Uncomplicated Pregnancy 4. Sodium Regulation in Preeclampsia 5. Cell Sodium Regulation in Uncomplicated Pregnancy 5.1. Cell Sodium and Cell (Na,K)ATPase or Sodium Pump (SP) in Uncomplicated Pregnancy 5.2. Other Cell Sodium Transport Systems in Uncomplicated Pregnancy 6. Cell Sodium Regulation in Preeclampsia 6.1. Cell Sodium and Potassium in P...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2009
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2008.12.3296